Muscle Activity in Upper Extremity Amputees

Purpose – Three interdependent studies designed as preliminary investigations of phantom and prosthetic limb control in upper extremity amputees. The purpose was to (1) compare muscle activation patterns of the phantom limb to anatomically expected patterns (2) compare muscle activation patterns of the phantom limb and those used to control a prosthesis (3) compare the use of upper arm muscle activity in phantom limb movements between users of different types of prosthetic devices. These studies aimed to expand the understanding of the role of the peripheral nervous system in movements of phantom and prosthetic limbs. Methods – Fifteen participants with varying levels of upper extremity amputations participated. Kinesiologic EMG (surface/fine wire) was utilized to examine residual limb muscle activation patterns during movements of the phantom and prosthesis. A series of phantom movements based on level of amputation were executed. After completing phantom limb movements participants donned their prosthesis and completed movements of the device. Muscles were considered active when the threshold of activity exceeded two standard deviations above rest trial. Visual analysis of EMG activity and goodness of fit Pearson Chi-Square tests were used to examine frequency occurrences in muscle activation patterns. Results –The majority of muscle activation patterns for the completion of phantom limb movements, regardless of the level of amputation, varied from anatomically expected muscle activation patterns. The majority of participants also used different muscle activation patterns to control similar movements of the phantom limb and prosthetic device. Finally, muscle activation patterns to control the movement of a phantom hand were different based on the type of device participants used, with body-powered prosthetic users activating muscles of the upper arm more frequently than myoelectric prosthetic users. Significance – This dissertation was a preliminary study into novel theories regarding phantom and prosthetic control. Results emphasize a dire need for future research to explore the injury response of the PNS, how this impacts phantom limb experiences, how these changes impact or is impacted by the CNS, and how to utilize the body’s natural response to injury to enhance control and function of prosthetic devices

Hand-to-Face Remapping But No Differences in Temporal Discrimination Observed on the Intact Hand Following Unilateral Upper Limb Amputation

Unilateral major limb amputation causes changes in sensory perception. Changes may occur within not only the residual limb but also the intact limb as well as the brain. We tested the hypothesis that limb amputation may result in the detection of hand sensation during stimulation of a non-limb-related body region. We further investigated the responses of unilateral upper limb amputees and individuals with all limbs intact to temporally based sensory tactile testing of the fingertips to test the hypothesis that changes in sensory perception also have an effect on the intact limb. Upper extremity amputees were assessed for the presence of referred sensations (RSs)—experiencing feelings in the missing limb when a different body region is stimulated, to determine changes within the brain that occur due to an amputation. Eight of 19 amputees (42.1%) experienced RS in the phantom limb with manual tactile mapping on various regions of the face. There was no correlation between whether someone had phantom sensations or phantom limb pain and where RS was found. Six of the amputees had either phantom sensation or pain in addition to RS induced by facial stimulation. Results from the tactile testing showed that there were no significant differences in the accuracy of participants in the temporal order judgment tasks (p = 0.702), whereby participants selected the digit that was tapped first by a tracking paradigm that resulted in correct answers leading to shorter interstimulus intervals (ISIs) and incorrect answers increasing the ISI. There were also no significant differences in timing perception, i.e., the threshold accuracy of the duration discrimination task (p = 0.727), in which participants tracked which of the two digits received a longer stimulus. We conclude that many, but not all, unilateral upper limb amputees experience phantom hand sensation and/or pain with stimulation of the face, suggesting that there could be postamputation changes in neuronal circuitry in somatosensory cortex. However, major unilateral limb amputation does not lead to changes in temporal order judgment or timing perception tasks administered via the tactile modality of the intact hand in upper limb amputees

Neuroimaging and Neuropsychological Studies in Sports-Related Concussions in Adolescents: Current State and Future Directions

Sports-related concussion, is a serious neurological concern that many adolescent athletes will face during their athletic careers. In some instances, the effects of sports-related head injury are long-lasting. Due to their still-developing brains, adolescents appear to be more vulnerable to long-term repercussions of these injuries. As all sports-related concussions are mild traumatic brain injuries (mTBI), this review we will examine the pathophysiology of mTBI, its acute effects and long-term risks from sustaining injury, and current and needed advancements in the areas of neuropsychological testing, accelerometer telemetry, and neuroimaging. Current methods do not adequately measure the extent of an injury that an athlete may sustain, potentially putting these athletes at a much greater risk for long-term effects. To better understand mTBI, neuropsychological testing best practices need to be developed, standardized, and implemented based on sound scientific evidence in order to be propagated as clinical guidelines. Wearable accelerometers can be used to assess thresholds for mTBI and cumulative effects of concussive and subconcussive injuries. Novel neuroimaging methods that can detect anatomical abnormalities and functional deficits with more specificity and sensitivity should be developed. Young athletes are particularly a vulnerable population warranting immediate and significant research aimed at protecting them against sports related injury and mitigating their long-term deficits

A Survey of Frozen Phantom Limb Experiences: Are Experiences Compatible With Current Theories

There are over two million individuals living with amputations in the United States. Almost all will experience the feeling of the amputated limb as still present, termed phantom limb sensation (PLS). Over 85% will also experience excruciatingly painful sensations known as phantom limb pain (PLP). Additionally some amputees also experience a sensation of the phantom limb in which the limb is immobile or stuck in a normal or abnormal anatomical position, termed frozen phantom sensations. When an amputee experiences a frozen limb they report that they are unable to move the limb, and sometimes report sensations of cramping and pain along with this immobility, fortunately not all frozen limbs are painful. Such sensations have previously been attributed to proprioceptive memories of the limb prior to amputation or a mismatch between visual feedback and proprioceptive feedback resulting from the initiation of a movement. Unfortunately there has been a dearth of research specifically focused on the frozen PLS. We conducted a survey to better elucidate and understand the characteristics and experiences of frozen PLSs. Results from the survey provided descriptions of a variety of frozen limb experiences, such as position and feelings experienced, combined with other phantom pain sensations, casting doubt on previous theories regarding frozen limbs. Further research needs to be focused on the etiology of phantom sensations and pain, which may not necessarily be maintained by the same processes, in order to understand better ways to treat PLP, increase mobility, and enhance amputees quality of life